Fig. 1

The schematic illustration represents the therapeutic potential of hepatocyte-like cell sheets differentiated from FIX-KI iPSCs edited by the CRISPR/Cas system. HE: hepatic endoderm, TCP: tissue culture plate, TRCD: temperature-responsive polymer-grafted temperature-responsive cell culture dish. Temperature reduction: from 37oC to room temperature. The figure made in BioRender.com