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Table 2 ANCOVA model for primary endpoints. Right ventricular cardiac function was adjusted for baseline values at three and twelve months

From: Autologous umbilical cord blood mononuclear cell therapy for hypoplastic left heart syndrome: a nonrandomized control trial of the efficacy and safety of intramyocardial injections

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Compared

Cardiac Function

n

Treatment group LS Means Estimate

(95% CI)

n

Control group

LS Means Estimate

(95% CI)

P

value (adjusted*)

Preop to 3 months

Apical FAC

40

-2.225

(-3.898, -0.552)

41

-2.511

(-4.164, -0.895)

0.80

(1.00)

Circumferen

tial Strain

30

1.341

(-0.310, 2.992)

35

0.170

(-1.358, 1.699)

0.302

(1.00)

Longitudinal Strain

39

0.539

(-0.607, 1.686)

39

-1.240

(-2.387, -0.094)

0.032

(0.19)

Preop to 12 months

Apical FAC

33

-3.897

(-5.680, -2.114)

32

-4.431

(-6.241, -2.620)

0.676

(1.00)

Circumferen

tial Strain

24

0.852

-1.001, 2.706)

20

2.159

(0.128, 4.190)

0.343

(1.00)

Longitudinal Strain

31

0.516

(-0.638, 1.715)

32

-0.453

(-1.633, 0.727)

0.254

(1.00)

  1. ANCOVA: Analysis of covariance; FAC: Fractional area change
  2. *Primary endpoints adjusted via the Bonferroni method to preserve the type I error rate