Fig. 7

Administration of miR-126-loaded CPC EVs (miR-126 + ELVs) in rats with I/R injury led to angiogenesis after 28 days (A–D). Immunofluorescence staining for detection of isolectin-B4⁺ capillaries, SMA⁺ arterioles, and MHC⁺ large vessel (A). Measuring the local density of the isolectin-B4⁺ area and vessel size (B), SMA⁺ arterioles (C), and MHC⁺ large vessel (D) in the myocardium. sEV-like vehicle: ELVs; SMA = smooth muscle actin; Small extracellular vesicles; sEVs; SM-MHC = smooth muscle-myosin heavy chain. Scale bar = 100 μm; One-way ANOVA with Tukey post hoc analysis. n.s. = not significant. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. [120].